Actifed is a combined medicine that helps to quickly get rid of the symptoms of influenza, rhinitis and other colds. Actifed is sold in Singapore and some other countries around the world.
Depending on the dosage form, Actifed may contain two or three active ingredients:
• Actifed tablets and syrup contain Pseudoephedrine and Triprolidine;
• Actifed expectorant contains Pseudoephedrine, Triprolidine, and Guaiphenesin;
• Actifed cough medicine contains Pseudoephedrine, Triprolidine and Codeine (or Dextromethorphan).
The variety of medicinal forms of Actifed allows the attending physician to recommend to the patient exactly the form of release that corresponds to his individual preferences the most.
Combination of several active ingredients in Actifed allows for greater effectiveness in the treatment of colds. Due to the multidirectional action of the components, Actifed acts on all links of the disease pathogenesis.
In addition, the possibility of using active substances dosages that are lower than in single-ingredient drugs increases the safety of Actifed in the treatment of respiratory diseases.
In best pharmacies of Singapore, patients can get Adapalene only with a prescription from the attending physician. If the patient, however, uses the services of one of the online pharmacies, he can buy Actifed without a prescription.
Active Ingredients of Actifed.
• Pseudoephedrine is an adrenomimetic that acts as a vasoconstrictor. Its therapeutic effect lies in reducing the edema of the mucous membrane of the upper respiratory tract.
• Triprolidine is a potent antihistamine. As part of Actifed, it acts as an antiallergic drug. At the same time, Triprolidine has a low anticholinergic activity, that is, it does not cause the effects that are characteristic of other antihistamines, like dry mouth, disruption of eye accommodation or tachycardia.
• Guaiphenesin is a highly effective expectorant. As part of Actifed, it has a mucolytic effect, which consists in lowering of the sputum viscosity and the activity intensification of the ciliary epithelium – the upper layer of the mucous membrane of the respiratory tract.
• While Guaiphenesin stimulates productive cough and expectoration, Codeine or Dextromethorphan (DXM) contribute to a lowering in the frequency and intensity of cough.
Unlike Codeine, which is an opiate, DXM does not affect the opiate receptors. By depressing the excitability of the cough center, DXM suppresses cough of any intensity and origin. It does not provide narcotic, analgesic and sedative effects.
To mitigate the symptoms of colds, no more than 3 Actifed tablets are sufficient for children aged more than 12 years and adults. Singapore Respiratory Specialists (SRS) recommend that the intervals between the tablets administration are at least 4-6 hours. One week of regular Actifed administration is sufficient to obtain recovery.
It is advisable to use Actifed expectorant in the complex treatment of respiratory diseases, when bronchial obstruction is impaired. The action of the expectorant is based on the stimulation of sputum excretion from the respiratory tract. Actifed promotes the formation of productive cough and improves the patency of the respiratory tract.
While the tablets can be used in children over 12 years of age, expectorant, syrup and cough syrup will help to get rid of colds in children from 6 years old.
The dosage regimens of Actifed liquid dosage forms do not differ in any way:
• Children aged 6 to 11 years: 5 ml, three times a day
• Children from 12 years of age and adults: 10 ml, three times a day
In addition, if the treating physician decides it is necessary, Actifed cough syrup with Codeine can be used to improve airway patency in children from the age of 2 years.
To date, Actifed is a popular drug for the treatment of colds, so its cost in pharmacies remains quite high. To save and not spend a significant amount of money, Singaporeans can buy cheap Actifed online.
Advantages of Actifed:
• lack of ability to provoke bronchospasm;
• simultaneous effect on the central and peripheral link of colds pathogenesis;
• does not cause drug dependence and does not exert a depressant effect on the respiratory center.
The main drawbacks of Actifed include the need to take the medicine 2-3 times a day. High multiplicity of use causes for the patient (especially a child) a lot of inconvenience and reduces adherence to treatment.
Actifed has been used in the treatment of colds for almost 60 years. The German company Aspen Bad obtained a marketing authorization for the sale of Actifed in Singapore in 1989. The drug is not the only trademark of Pseudoephedrine and Triprolidine. The Singaporeans have the opportunity to use another combined drug for the treatment of colds – Fedac.
The drug, which is sold under the trademark Actifed, not always contained the same ingredients. In Singapore, Thailand, Italy and the UK, the original Actifed formula that contains Pseudoephedrine and Triprolidine is used to treat respiratory diseases. Previously, the combined drug was available for sale in the US.
However, in 2006, the FDA considered that the administration of drugs with Pseudoephedrine and Triprolidine increased the risk of drug dependence. Therefore, the original formula of Actifed for the United States was changed and contained Phenylephrine and Chlorpheniramine.
Soon after Actifed went on sale with a new formula of active ingredients, however, Americans began to complain to their attending physicians about the ineffectiveness of the drug in the therapy of respiratory diseases. In the end, Actifed was withdrawn from sale in the US.
Currently, online pharmacies are increasingly being used as a means to obtain a broad access to Actifed in Singapore. The main advantages of online pharmacies are low price for the drug, as well as the opportunity to get it without a prescription.